After Acme products fail him one too many times in his dogged pursuit of the Roadrunner, Wile E. Coyote decides to hire a billboard lawyer to sue the Acme Corporation.

Four years have passed since the events of No Way Home, and Peter is now an adult living entirely alone, having voluntarily erased himself from the lives and memories of those he loves. Crime-fighting in a New York that no longer knows his name, he's devoted himself entirely to protecting his city — a full-time Spider-Man — but as the demands on him intensify, the pressure sparks a surprising physical evolution that threatens his existence, even as a strange new pattern of crimes gives rise to one of the most powerful threats he has ever faced.

Gemma, a young mother raising her daughter in the house she grew up in, discovers she can travel into The Further, where she possesses an ability to bring what lives there back to the real world.